Day: September 18, 2020

87219-29-2, (S)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

87219-29-2, To a solution of (3S)-(-)-tetrahydro-5-oxo-3-furanylcarbamic acid benzyl ester (3.3 g) in tetrahydrofuran (20 mL) were added di-tert-butyl dicarbonate (4.1 g) and 10% palladium on carbon (0.4 g), followed by stirring for 1 day under hydrogen atmosphere. Any insoluble matter was removed by filtration through a Celite pad, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane : ethyl acetate = 4:1), to thereby give the title compound (1.5 g).1H-NMR(CDCl3) delta:1.45(9H, s), 2.45(1H, dd, J=17.8, 2.7Hz), 2.86(1H, dd, J=17.8, 7.3Hz), 4.12-4.23(1H, m), 4.54-4.62(2H, m), 4.85-4.95(1H, m).

The synthetic route of 87219-29-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1577301; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of the compound obtained above (2.8 mmol), (S)- aminotetrahydrofuran hydrochloride (346 mg, 2.8 mmol) and DIEA (1.0 mL, 2.1 mmol) in DCM (6 mL) was stirred at -70 C (C02/i-PrOH) under an atmosphere of nitrogen. After 30 minutes the cooling bath was removed and the mixture was stirred overnight at room temperature. TLC analysis of the crude reaction mixture ([EtOAc/hexanes (3:7)] Rf = 0.56) showed the reaction to be complete. To the brown solution was then added DCM (2 mL), trans-4-aminocyclohexanol (323 mg, 2.8 mmol) and DIEA (1.0 mL, 2.1 mmol), and the reaction flask was sealed and stirred at 45 C overnight. After cooling to room temperature the contents of the reaction flask was added to a saturated NH4CI solution (25 mL) and water (10 mL). The product was extracted [2 x DCM (10 mL)] from the aqueous solution, dried (Na2S04) and the solvent was removed under reduced pressure. The crude product was purified by flash chromatography over silica gel [EtO Ac/heptane (9: 1), EtOAc] to provide 0.49 g (54%) of the target compound as a light yellow solid. TLC (EtO Ac) Rf = 6.27. HPLC conditions C, RT = 13.63 min (CP: 95.9%, radiochemical purity (RCP): 98.1%), 204512-95-8

As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.

Reference£º
Patent; SIGNAL PHARMACEUTICALS, LLC; BEAUCHAMPS, Marie, Georges; HARRIS, Louise, Michelle; KOTHARE, Mohit, Atul; SAINDANE, Manohar, T.; WO2011/71491; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

5- (naphthalen-1-ylmethyl) isoxazole-3-carboxylic acid (123 mg, 0.49 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (123 mg, 0.90 mmol), Triethylamine (0.23 mL, 1.66 mmol) And 1-hydroxybenzotriazole (9 mg, 0.06 mmol) Was added to chloroform (amylene addition product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (159 mg, 0.83 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Indicated below N- (tetrahydrofuran-3-ylmethyl) -5- (naphthalen-1-ylmethyl) isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (160)) 95 mg was obtained., 184950-35-4

184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.

5061-21-2, Example I: Synthesis of 3- (4-nitrophenvnsulfanyl1dihvdrofuran-2(3H)-oneTo a solution of p-nitro thiophenol (10.0 g, 0.0645 mol) in dichloromethane (75 mL) under argon atmosphere at about 0C, was added triethyl amine (19.4 g, 0.1935 mol) and then added a solution of bromolactone (11.1 g, 0.067 mol) in dichloromethane (75 mL) drop wise. The reaction mixture was stirred for about 30 minutes. Subsequently, the crude compound was obtained by adding water to the reaction mixture and extracting in dichloromethane. The organic layer was dried with sodium sulphate and concentrated, purified by silica gel column, using 30% ethyl acetate/hexane as eluent to obtain the title compound.Yield: 11 gSynthetic procedure for Scheme I:

5061-21-2 2-Bromo-4-butanolide 95463, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; KHERA, Manoj Kumar; SONI, Ajay; SATTIGERI, Jitendra; SATTIGERI, Viswajanani; DAS, Biswajit; CLIFFE, Ian A.; BHATNAGAR, Pradip Kumar; RAUF, Abdul Rehman Abdul; MUSIB, Arpita; SAHA, Subham; YADAV, Neeraj Kumar; AHAMMED, Sabir; REDDY, Ranadheer R.; RAY, Abhijit; SRIVASTAVA, Punit; DASTIDAR, Sunanda Ghosh; WO2012/38942; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.

A stirring solution of compound 24-1 (55 mg, 0.10 mmol), DMAP (14.8 mg, 0.12 mmol) and 2,2-dimethylsuccinic anhydride (38.7 mg, 0.30 mmol) in dry pyridine (1.0 mL) is heated at 1200C for 4 hours. Another 0.30 mmol of 2,2-dimethylsuccinic anhydride is added and heating at 12O0C is continued for 24 hours. The mixture is cooled down to room temperature and concentrated to dryness. The residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash column chromatography on silica gel (methanol/ DCM 0percent to 10percent) to yield the title compound 19-2 as a white solid (48 mg, 71percent). 1H NMR (400 MHz, CDCl3): delta [ppm] 7.71 (m, 2H), 7.50 (m, 1 H), 7.42 (m, 2H), 6.11 (s, 1 H), 4.48 (d x d, 1 H), 3.17 (m, 1 H), 2.90 (d, 1 H), 2.83 (d, 1 H), 2.66 (d, 1 H), 2.55 (d, 1 H), 2.41 (d, 1 H), 2.36 (d, 1 H), 1.95 (m, 3H), 1.76 – 1.16 (m, 26H), 1.13 (s, 3H), 0.97 (s, 3H), 0.87 (s, 3H), 0.83 (s, 3H), 0.79 (s, 3H). LC/MS: m/z = 674.70 (M+H+).

17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.

Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/82819; (2009); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89364-31-8,Tetrahydrofuran-3-carboxylic acid,as a common compound, the synthetic route is as follows.,89364-31-8

To a solution of tetrahydrofuran-3-carboxylic acid (0.247 mL, 2.58 mmol) in THF (13 mL) at 0 ¡ãC was added slowly lithium aluminium hydride (1 .0 M in THF, 5.2 mL, 5.16 mmol), stirred for 10 minutes then allowed to attain room temperature and stirred for a further 3 hours. The reaction mixture was cooled to 0 ¡ãC and diluted with diethyl ether (15 mL), then treated sequentially with water (0.2 mL), NaOH (15percent solution, 0.2 mL) and water (0.6 mL) and stirred for 30 minutes. The white suspension was then treated with sodium sulfate, stirred for a further 20 minutes, filtered over celite, washed with diethyl ether (2x 20 mL) and concentrated in vacuo to yield 224 mg (85percent) of the title compound as a colourless oil which was carried forward to the next stage without further purification. -NMR Spectrum: deltaEta (500 MHz, CDCI3): 3.90-3.84 (2H, m), 3.78-3.73 (1H, m), 3.66-3.63 (2H, m), 3.61-3.57 (1H, m), 2.51-2.46 (1H, m), 2.08-2.01 (1H, m), 1.69-1.62 (1H, m)

As the paragraph descriping shows that 89364-31-8 is playing an increasingly important role.

Reference£º
Patent; ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED; CHESSARI, Gianni; HOWARD, Steven; BUCK, Ildiko Maria; CONS, Benjamin David; JOHNSON, Christopher Norbert; HOLVEY, Rhian Sara; REES, David Charles; ST. DENIS, Jeffrey David; TAMANINI, Emiliano; GOLDING, Bernard Thomas; HARDCASTLE, Ian Robert; CANO, Celine Florence; MILLER, Duncan Charles; CULLY, Sarah; NOBLE, Martin Edward Maentylae; OSBORNE, James Daniel; PEACH, Joanne; LEWIS, Arwel; HIRST, Kim Louise; WHITTAKER, Benjamin Paul; WATSON, David Wyn; MITCHELL, Dale Robert; (293 pag.)WO2017/55860; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63095-51-2,(R)-4-Propyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.

63095-51-2, Under the protection of nitrogen, brivaracetam intermediate III (128.1g, 1 mol) was dissolved in 1L in methylene chloride. Lower the temperature to 0 C. Add trimethylsilyl iodide (150 ml). The reaction solution at 20-30 C was stirred for 2 hours. Followed by adding hydrochloric acid solution (1M, 800 ml) and sodium thiosulfate aqueous solution (mass percentage of 10%, the quality percent means that the quality of the sodium thiosulfate with the percentage of the total mass of the aqueous solution of sodium thiosulfate, 400 ml. ), The aqueous phase is 1L dichloromethane extraction, the organic phase with saturated salt water washing twice, dried with anhydrous sodium sulfate, filtered, concentrated under reduced pressure to obtain brivaracetam intermediate IV (254.6g), yield 99.5%, purity: 95.6% (GC).

63095-51-2 (R)-4-Propyldihydrofuran-2(3H)-one 10997054, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Bocimed Pharmaceutical Co., Ltd.; Ying, Shuhuan; Pi, Hongjun; Chen, Jian; Zhou, Wei; Zhang, Jueming; (13 pag.)CN106588741; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.,88675-24-5

In a 4 mL vial was mixed the 2-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrimidine (61 mg, 0.25 mmol), tetrahydrofuran-3 -amine (22 mg, 0.25 mmol) and TEA (46 uL, 0.36 mmol) in EtOH (0.3 mL). The reaction was heated to 95 ¡ãC for 2 h before being cooled and concentrated. To the crude residue was added the 2′-bromo-6’H,8’H-spiro[chromane-4,9′-pyrido[3′,2′:4,5]imidazo[2,l-c][l,4]oxazine] (39 mg, 0.10 mmol, Preparation 86), Pd2(dba)3 (9.6 mg, 0.010 mmol), l,3,5,7-Tetramethyl-2,4,8-trioxa-6- phospha-adamantane (6.1 mg, 0.020 mmol) and CS2CO3 (74.8 mg, 0.25 mmol). THF (1 mL) and H20 (0.25 mL) were added, and the reaction was stirred at 60 ¡ãC for 18 h before being cooled to rt and concentrated. The residue was dissolved in 1 : 1 MeOH/DMSO and purified by reverse phase chromatography using a gradient of MeCN (A) and 0.1percent TFA in H20 (B) at a flow rate of 50 mL/min (0- 0.5 min 5percent A, 0.5-8.5 min linear gradient 05-100percent A, 8.7-10.7 min 100percent A, 10.7-11 min linear gradient 100-05percent A) to yield the title compound. (39 mg, 33percent); LC/MS (Table 1, method ai) Rt = 0.61 min; MS 111 ~ 457 (M+H)+. (TNF IC50= B).

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; ABBVIE INC.; BREINLINGER, Eric, C.; COX, Phil, B.; DAANEN, Jerome; DIETRICH, Justin; DJURIC, Stevan; DOMBROWSKI, Amanda, W.; FRANK, Kristine, E.; FRIEDMAN, Michael, M.; GOMTSYAN, Arthur; LI, Huan-Qui; LONGENECKER, Kenton; OSUMA, Augustine; ROWLEY, Ann, Marie; SCHMIDT, Robert; VASUDEVAN, Anil; WILSON, Noel; (378 pag.)WO2016/168641; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (1-fluoro-2-naphthylmethoxymethyl) isoxazole-3-carboxylic acid (0.59 g, 1.5 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.83 g, 6.0 mmol), Triethylamine (0.61 g, 6.0 mmol) And 1-hydroxybenzotriazole (0.06 g, 0.4 mmol) Was added to chloroform (amylen added product) (4 mL) and tetrahydrofuran (4 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.92 g, 4.8 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain the compound represented by the following formula Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (1-fluoro-2-naphthylmethoxymethyl) isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (258)) 0.07 g was obtained.

184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.204512-95-8,(S)-Tetrahydrofuran-3-amine hydrochloride,as a common compound, the synthetic route is as follows.

To a stirred solution of (S)-3-aminotetrahydrofuran hydrochloride (16.0g, 130mmol) in anhydrous THF (250mL) at 0C was added dropwise Et3N (41.5mL, 298mmol) within 20min and stirred another 20min, then a solution of benzyl 2-bromoacetate (29.6g, 130mmol) was added slowly at 0C followed by NaI (1.90g, 13.0mmol). The reaction mixture was stirred at 0C for 30min and then allowed to warm to room temperature and stirred overnight. The solvent was removed under diminished pressure and the residue was treated with water (200mL) and extracted with three 150mL portions of ethyl acetate. The combined organic extracts were dried over Na2SO4 and concentrated under diminished pressure. The residue was purified by chromatography on a silica gel column (30¡Á6cm). Elution with 3:1 hexanes-ethyl acetate gave 3a as a yellow oil: yield 17.1g (56.1%). 1H NMR (400MHz, CDCl3) delta 7.39-7.30 (m, 5H), 5.16 (s, 2H), 3.91 (dd, J=15.6, 7.6Hz, 1H), 3.80-3.74 (m, 2H), 3.57 (dd, J=9.2, 3.6Hz, 1H), 3.44 (d, J=1.2Hz, 2H), 3.41-3.36 (m, 1H), 2.08-2.00 (m, 1H), 1.76-1.68 (m, 2H); LC-MS (ESI) [M+H]+ m/z 236.2.

204512-95-8, 204512-95-8 (S)-Tetrahydrofuran-3-amine hydrochloride 18664284, aTetrahydrofurans compound, is more and more widely used in various fields.

Reference£º
Article; Bai, Xiaoguang; Yang, Zhiheng; Zhu, Mei; Dong, Biao; Zhou, Lei; Zhang, Guoning; Wang, Juxian; Wang, Yucheng; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 30 – 44;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem