Simple exploration of 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.

To a toluene solution (10 mL) of 5- (benzo [b] thiophen-2-ylmethyl) isoxazole-3-carboxylic acid chloride ( Tetrahydrofuran-3-ylmethylamine hydrochloride (150 mg, 1.09 mmol) And 1 mol / L sodium hydroxide aqueous solution (8 mL) were simultaneously added under cooling with ice water. After vigorously stirring for 30 minutes under cooling with ice water, The reaction mixture was extracted once with ethyl acetate. The organic layer was washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (Tetrahydrofuran-3-ylmethyl) -5- (benzo [b] thiophen-2-ylmethyl) isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (161)) 104 mg., 184950-35-4

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem