204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
S-(-)-3-Aminotetrahydrofuran hydrochloride (149 mg, 1.20 mmol) and diisopropylamine (0.70 mL, 4.0 mmol) were added to 4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydroindazol-1-yl)-2-fluorobenzonitrile (311 mg, 1.00 mmol) in DMSO (0.7 mL). The mixture was stirred at 60 C. for 48 hours. It was diluted with EtOAc (10 mL) and washed with H2O (10 mL) and sat. NaCl (10 mL). The material was concentrated and passed through a plug of silica eluting with EtOAc. After the solvent was removed, the white solid was dissolved in DMSO (0.4 mL) and EtOH (1.6 mL). To the solution were added 1 M NaOH (0.2 mL) and 30% H2O2 (0.2 mL). The reaction was stirred at 25 C. for 1 hour. It was diluted with EtOAc (10 mL) and washed with H2O (10 mL) and sat. NaCl (10 mL). The organic layer was dried over Na2SO4 and concentrated. Purification by gradient flash chromatography eluting with 0% to 100% EtOAc in hexanes provided (S)-4-(3-ethyl-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide (251 mg, 63%) as a white solid (LC/MS m/z=397.1 [M+H]+). 1H NMR (DMSO, 20 C., 400 MHz) delta (ppm) 8.56 (d, 1H), 7.75 (d, 2H), 6.72 (s, 1H), 4.18 (s, 1H), 4.12 (q, 1H), 4.02-3.53 (m, 8H), 2.48 (s, 4H), 1.17 (t, 3H), 1.00 (s, 6H)., 204512-95-8
As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.
Reference£º
Patent; Huang, Kenneth He; Ommen, Andy J.; Barta, Thomas E.; Hughes, Philip F.; Veal, James; Ma, Wei; Smith, Emilie D.; Woodward, Angela R.; McCall, W. Stephen; US2008/269193; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem