With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16874-33-2,Tetrahydrofuran-2-carboxylic acid,as a common compound, the synthetic route is as follows.
2-tetrahydrofurancarboxylic acid (5 mmol, 580 mg), 10% Pd/C (0.05 mmol, 50 mg) was sequentially added to a 25 ml hastelloy autoclave. La(OTf)3 (0.1 mmol, 62 mg) and 10 ml of acetic acid. After replacement by N2, H2 was charged to 15 atm. The mixture was heated to 170 C with stirring for 6 h. After the reaction was completed, it was cooled to room temperature and the gas was carefully released. The reaction solution was filtered to recover a Pd/C hydrogenation catalyst. The reaction solution passed the gas phase test. the yield of 1,4-butanediol diacetate was 60.3%., 16874-33-2
16874-33-2 Tetrahydrofuran-2-carboxylic acid 86079, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; University of Science and Technology of China; Deng Jin; Gong Baoxiang; Shi Jing; Fu Yao; (9 pag.)CN110218152; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem