With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.165253-29-2,3-(Bromomethyl)tetrahydrofuran,as a common compound, the synthetic route is as follows.
To a saturated aqueous sodium sulfite solution (10 mL) was added 3- (bromomethyl) tetrahydrofuran (1.00 g, 6.06 mmol).The reaction mixture was warmed to reflux for 24 hours,And then concentrated under reduced pressure.To the resulting residue was added ethanol (20 mL)The resulting mixture was warmed to 50 ¡ã C,Stir for 30 minutes,Immediately filter hot.The filtrate was concentrated under reduced pressure to give the title compound as a white solid(875.3 mg, yield 76.8percent).
165253-29-2, 165253-29-2 3-(Bromomethyl)tetrahydrofuran 14173422, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Sunshine Lake Pharma Co., Ltd.; Xi, Ning; Dai, Weilong; Li, Minxiong; Chen, Wuhong; Zhang, Tao; Hu, Haiyang; Li, Xiaobo; Liu, Jun; Wang, Tingjin; (146 pag.)CN106478651; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem