With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
To a stirred solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy- 5a,5b,8,8,11a-pentamethyl-N-(1-(5-phenyl-1H-imidazol-2-yl)cyclopropyl)-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxamide (Step 2 Example 19, 0.2 g, 0.31 mmol) and 2,2-dimethyl succinicanhydride (0.16 g, 1.2 mmol) in toluene (7 ml), was added DMAP (0.076 g, 0.6 mmol). The reaction mixture was heated at 90 C for 12 h. After completion of the reaction (monitored by TLC), reaction mixture was concentrated under reduced pressure, cooled to 0 C, acidified to pH = 6 with IN HCl and extracted with DCM. The combined organic extracts was washed with water, brine, dried over Na2SO4 then the solvent was evaporated under reduced pressure and to the resulting solid was recrystallized from ACN to give the title compound as a white solid (0.11 g, Yield: 45.83%). 1H NMR (300 MHz, DMSO-d6): delta 12.15 (s, 1H), 11.27 (s, 1H), 8.37 (s, 1H), 7.72-7.70 (m, 2H), 7.39 (s, 1H), 7.31-7.26 (m, 2H), 7.15-7.11 (m, 1H), 4.61 (s, 1H), 4.51 (s, 1H), 4.37-4.32 (m, 1H), 3.00-2.94 (m, 1H), 2.27 (m, 1H), 1.98-1.95 (m, 1H), 1.79-1.73 (m, 1H), 1.62-1.00 (m, 32H), 0.91-0.74 (m, 19H). ESI Mass: 766.56 [M+H]+., 17347-61-4
The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; NEELA, Sudhakar; MOGILI, Narsingam; (87 pag.)WO2017/21922; (2017); A1;,
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