204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
(3S)-Oxolan-3-amine hydrochloride (83 mg, 0.67 mmol) was added at room temperature to a stirred suspension of 8 -bromo- 1 -(3 ,4-dichlorob enzyl)-3 , 7-dimethyl- 1H- purine-2,6(3H,71])-dione (70 mg, 0.17 mmol) and DIEA (233 pi, 1.34 mmol) in nBuOH (5 ml). The resulting mixture was heated at 120C and stirred for 20h. Further (3S)-oxolan-3- amine hydrochloride (83 mg, 0.67 mmol) and DIEA (233 pi, 1.34 mmol) were added. The temperature was increased to 130C and stirring was continued. After 24h the solvent was removed in vacuo and the residue was purified by prep-HPLC to obtain the title compound. ?HNMR (500 MFIz, DMSO-d6) 7.55 (d, J 8.3 Hz, 1H), 7.51 (d, J 1.9 Hz, 1H), 7.25 (dd, J= 8.3, 2.0 Hz, 1H), 7.12 (d, J= 6.3 Hz, 1H), 4.98 (s, 2H), 4.47 -4.31 (m, 1H), 3.94- 3.84 (m, 2H), 3.72 (td, J= 8.1, 6.0 Hz, 1H), 3.61 (dd, J= 9.0, 4.1 Hz, 1H), 3.58 (s, 3H), 3.35 (s, 3H),2.38-2.07(m, 1H), 1.99- 1.78 (m, 1H).
204512-95-8, As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.
Reference£º
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel, P.; SAIAH, Eddine; LECCI, Cristina; PACE, Robert, David, Matthew; TYE, Heather; VILE, Julia; (420 pag.)WO2017/106352; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem