With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.165253-29-2,3-(Bromomethyl)tetrahydrofuran,as a common compound, the synthetic route is as follows.
Potassium carbonate (67 mg, 0.486 mmol) is added to a solution of 4-(2,5-dioxo-l-(3-(tri- fluoromethyl)phenyl)-l,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile (example 1, 100 mg, 0.243 mmol) in N,N-dimethylformamide (3 mL). 3-(Bromomethyl)tetrahydrofuran (60 mg, 0.365 mmol) is added, and the mixture is stirred at room temperature for 1 h and purified by reversed phase HPLC (Waters Xbridge?-Cis, gradient of acetonitrile in water, 0.1percent NH3). Yield: 12 mg; ESI mass spectrum [M+H]+ = 496; Retention time HPLC: 0.91 min (Z011_S03)., 165253-29-2
The synthetic route of 165253-29-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GNAMM, Christian; OOST, Thorsten; PETERS, Stefan; RUDOLF, Klaus; HOESCH, Holger; RIES, Uwe Joerg; WO2014/135414; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem