With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.89364-31-8,Tetrahydrofuran-3-carboxylic acid,as a common compound, the synthetic route is as follows.
Step 1 : To a solution of tetrahydrofuran-3-carboxylic acid (600 mg, 5.17 mmol) in THF (15 mL) was added a solution of 1 M BH3 THF in THF (10.3 mL, 10.3 mmol) at 0 C. The reaction was heated to 65 C and stirred for 12 hours. The solution was then cooled to 20 C and MeOH (4 mL) was added. The reaction was then stirred at 65 C for 2 hours before cooling to RT and concentrated in vacuo. The residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and petroleum ether to give (tetrahydrofuran-3-yl)methanol 200 mg (38%), 89364-31-8
As the paragraph descriping shows that 89364-31-8 is playing an increasingly important role.
Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; JESSING, Mikkel; (126 pag.)WO2016/55618; (2016); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem