17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-N-(1-(5-(4- fluorophenyl)-1H-imidazol-2-yl)cyclobutyl)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxamide (Step 2, Example 15, 0.15 g, 0.22 mmol) and 2,2-dimethyl succinic anhydride (0.11 g, 0.89 mmol) in toluene (5 ml), was added DMAP (0.055 g, 0.44 mmol). The reaction mixture was heated at 90C for about 12 hours. After completion of the reaction (monitored by TLC), the reaction mixture was concentrated under reduced pressure, cooled to 0C, acidified to pH=6 with 1N HCl and extracted with DCM. The combined organic extracts were washed with water, brine, dried over Na2SO4 then the solvent was evaporated under reduced pressure and the resulting solid was recrystallized from ACN to give the title compound (0.08 g, yield: 45%). 1H MR (300 MHz, DMSO-D6): delta 12.15 (s, 1H), 11.47 (s, 1H), 8.14 (s, 1H), 7.76 (dd, J = 6.0 Hz, 8.7 Hz, 2H), 7.41 (s, 1H), 7.13 (dd, J = 8.7 Hz, 8.7 Hz, 2H), 4.60 (s, 1H), 4.50 (s, 1H), 4.37-4.31 (m, 1H), 2.94-2.91 (m, 1H), 2.65-2.32 (m, 8H), 1.99-1.01 (m, 29H), 0.90-0.68 (m, 19H); ES Mass: 798.5 [M+H]+., 17347-61-4
The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; HETERO RESEARCH FOUNDATION; BANDI, Parthasaradhi Reddy; KURA, Rathnakar Reddy; GAZULA LEVI, David Krupadanam; ADULLA, Panduranga Reddy; NEELA, Sudhakar; MOGILI, Narsingam; (87 pag.)WO2017/21922; (2017); A1;,
Tetrahydrofuran – Wikipedia
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