With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
A stirring solution of compound 16-2 (121 mg, 0.207 mmol), DMAP (30 mg, 0.248 mmol) and 2,2-dimethylsuccinic anhydride (80 mg, 0.620 mmol) in dry pyridine (2 mL) is heated for 6 hours at 120¡ãC. Another 80 mg (0.62 mmol) of anhydride is added and heating is continued overnight. The mixture is concentrated to dryness and the residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash chromatography on silica gel (ethyl acetate/hexanes 20percent to 60percent) to give the title compound 1 1-3 as a glass (127 mg, 86percent).1H NMR (400 MHz, CDCl3): delta [ppm] 4.70 (d, 1 H), 4.60 (s, 1 H), 4.46 (m, 2H), 3.75 (s, 3H), 2.80 (m, 1 H), 2.63 (m, 1 H), 2.45 (m, 2H), 2.30 (d x d, 1 H), 2.03 (m, 1 H), 1.85 (m, 1H), 1.70-0.80 (m, 20H), 1 .67 (s, 3H), 1.26 (s, 3H), 1 .23 (s, 3H), 1.03 (s, 3H), 0.99 (s, 3H), 0.98 (s, 3H), 0.81 (s, 3H), 0.79 (s, 6H). LC/MS: m/z = 713.77 (M+H+).
17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.
Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/100532; (2009); A1;,
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