With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.,17347-61-4
Example 25 : Preparation of 4-(((l S,3aS,5aR,5bR,7aR,9S, 11 aR, 1 IbR, 13aR, 13bR)-l – isopropyl-3a-((S)-2-(5-(4-metho xyphenyl)-lH-imidazol-2-yl)pyrro lidine- 1 -carbonyl)- 5a,5b,8,8,l la-pentamethylicosahydro-lH-cyclopenta[a]chrysen-9-yl)oxy)-2,2-dimethyl-4- oxobutanoic acid: [0210] To a stirred solution of ((lS,3aS,5aR,5bR,7aR,9S,l laR,l lbR,13aR,13bR)-9- hydroxy- 1 -isopropyl-5 a,5b,8,8, 11 a-pentamethylicosahydro-3aH-cyclopenta[a]chrysen-3a- yl)((S)-2-(5-(4-methoxyphenyl)- lH-imidazol-2-yl)pyrrolidin- 1 -yl)methanone (Example 24- step 2, 0.2 g, 0.29 mmol) and 2,2-dimethyl succinicanhydride (0.14 g, 1.17 mmol) in toluene (6 mL) was added DMAP (0.07 g, 0.58 mmol). The reaction mixture was heated at 90¡ãC for 12 hours. After completion of the reaction (monitored by TLC), reaction mixture was concentrated under reduced pressure, cooled to 0¡ãC, acidified to pH = 6 with IN HC1 and extracted with DCM. The combined organic extracts were washed with water, brine, dried over Na2S04. Then the solvent was evaporated and to the resulting solid was recrystalised from ACN to give the title compound (0.09 g, Yield 26percent) as a white solid. 1H-NMR, CDC13, 300 MHz): delta 7.49- 7.47 (m, 2H), 7.12 (s, 1H), 6.89 (d, J = 8.7 Hz, 2H), 5.36- 5.34 (m, 1H), 4.54- 4.49 (m, 1H), 3.81 (s, 3H), 3.68- 3.56 (m, 2H), 2.94- 2.90 (m, 2H), 2.71- 1.12 (m, 36H), 0.99- 0.84 (m, 18H), 0.72 (d, J = 6.6 Hz, 3H); ESI MS: 812.5 (M+H).
As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.
Reference£º
Patent; HETERO RESEARCH FOUNDATION; PANDURANGA REDDY, Adulla; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; VL SUBRAHMANYAM, Lanka; DAVID KRUPADANAM, Gazula, Levi; VENKATI, Mukkera; SUDHAKAR, Neela; SRINIVAS REDDY, Kallem; WO2014/105926; (2014); A1;,
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