With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.
(1) Under ice water bath conditions, 169 mg (0.93 mM) of (R)-(+)-alpha-amino-gamma-butyrolactone hydrochloride and 0.93 mM of p-bromobenzylsulfonyl chloride were placed in 10 mL of dry CH2Cl2 solution and mixed evenly. Afterwards, add 267 mg (1.5 mM) 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and 68 mg (0.6 mM) of 4-dimethylaminopyridine (DMAP). After stirring for 30 min, the ice bath was removed and the reaction was continued for 20 h at room temperature.(2) The solution after the reaction was diluted to CH2Cl2 to a final volume of 100 mL, and the solution was washed three times with an equal volume of 10% (v / v) HCl solution and saturated NaCl solution in a separatory funnel. After the organic phase solution was collected, the residual water in the organic phase was removed by addition of anhydrous MgSO4 and dried at 50 C by rotary evaporator to give the crude product. The crude product was purified by SiO2 column chromatography, TLC, ethyl acetate: petroleum ether = 1.5: 1. The eluate was rotated by rotary evaporator at 50 C and the oil pump was decompressed under reduced pressure to obtain the desired product.
42417-39-0, As the paragraph descriping shows that 42417-39-0 is playing an increasingly important role.
Reference£º
Patent; Lanzhou University; Li, Hongyu; Zhao, Yang; Liu, Yingqian; (9 pag.)CN106146432; (2016); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem