With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13031-04-4,4,4-Dimethyldihydrofuran-2,3-dione,as a common compound, the synthetic route is as follows.
General procedure: Hydrogenations were performed in an atmospheric batch reactor. The catalytic system including catalyst (25 mg) and 5 mL of solvent (toluene or toluene and AcOH mixture) was loaded into the reactor and purged three times with H2. The catalyst was stirred and pre-hydrogenated for 30 min. The calculated amount of modifier was injected and after 0.5-1 min 1 mmol (128 mg) of KPL was added and stirred in the presence of H2 for the required reaction time. Standard conditions were: 25 mg Pt/Al2O3, 5 mL solvent, [modifier] 0.1 mM/L, 0.1 MPa H2 pressure, 294-297 K, ~ 900 rpm (diffusion control free reaction), and 1 mmol (128 mg) of KPL. The product identification and the enantiomeric excess, ee% = |[R] – [S]| ¡Á 100 / ([R] + [S]) were monitored by gas chromatography (HP 6890 N GC-FID using 30 m long Cyclodex-B capillary column, head pressure 21.65 psi He, and column temperature 398 K. Retention times (min): 10.6 of (S)-PL, and 11.2 of (R)-PL. The reproducibility was ¡À 2%., 13031-04-4
As the paragraph descriping shows that 13031-04-4 is playing an increasingly important role.
Reference£º
Article; Szollosi, Gyoergy; Balazsik, Katalin; Bucsi, Imre; Bartok, Tibor; Bartok, Mihaly; Catalysis Communications; vol. 32; (2013); p. 81 – 85;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem