With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
Ethyl 3-butyl-1,2,4-oxadiazole-5-carboxylate (0.40 g, 2 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (2.75 g, 20 mmol) And diisopropylethylamine (2.58 g, 20 mmol) Was added to ethanol (40 mL) And the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, Water was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -3-butyl-1,2,4-oxadiazole-5-carboxamide (Hereinafter referred to as amide compound (58)) 0.43 g.
184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
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