With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
Tetrahydrofuran-3-ylmethylamine hydrochloride (0.07 g, 0.49 mmol) And triethylamine (0.05 g, 0.49 mmol) Was added to chloroform (amylene addition product) (3 mL). To the mixture, At room temperature 5- (1,4-benzodioxan-2-ylmethyl) oxymethyl isoxazole-3-carboxylic acid (0.12 g, 0.41 mmol) 1-Hydroxybenzotriazole (0.01 g, 0.04 mmol) And 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.10 g, 0.49 mmol) were added, After stirring at room temperature for 6 hours, Dilute hydrochloric acid was added, It was extracted twice with chloroform. The organic layer was washed with saturated sodium bicarbonate water, After drying with anhydrous sodium sulfate, It was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5- (1,4-benzodioxan-2-ylmethyl) oxymethyl isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (120)) 0.08 g was obtained.
184950-35-4, The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
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