88675-24-5,88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (S)-3-(1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(3-(((R)-2-ethyl-2,3- dihydropyrido[3,4-f][1,4]oxazepin-4(5H)-yl)methyl)-4-methylphenyl)-2,2-dimethylpropanoic acid (100 mg, 0.190 mmol) and tetrahydrofuran-3-amine (19.81 mg, 0.227 mmol) in N,N- dimethylformamide (DMF) (1 mL) was added DIEA (0.099 mL, 0.569 mmol) and HATU (72.1 mg, 0.190 mmol). The mixture was allowed to stir at 25 C for 20 hrs. The reaction was then diluted with water and extracted with ethyl acetate (3×30 mL). The combined organic layer was dried over magnesium sulfate, filtered, and concentrated to dryness. The residue was dissolved in 3 mL of DMSO, filtered, and purified by reverse phase preparative HPLC under neutral conditions to obtain the title compound (42.9 mg, 0.072 mmol, 37.9 % yield) as a colorless solid. LC-MS m/z 598.5 (M+H)+, 0.88 min (ret. time).1H NMR (400 MHz, METHANOL-d4) deltappm 0.82 – 1.00 (m, 3 H) 1.30 – 1.39 (m, 7 H) 1.39 – 1.68 (m, 3 H) 1.89 – 2.04 (m, 1 H) 2.26 (s, 3 H) 2.68 – 2.90 (m, 5 H) 3.17 – 3.29 (m, 1 H) 3.55 – 3.78 (m, 6 H) 3.81 – 3.99 (m, 2 H) 4.15 – 4.33 (m, 4 H) 4.89 (d, J=7.53 Hz, 1 H) 6.98 (d, J=5.52 Hz, 1 H) 7.04 – 7.19 (m, 3 H) 7.48 (d, J=8.78 Hz, 1 H) 7.69 – 7.80 (m, 1 H) 8.09 (s, 1 H) 8.30 (d, J=5.27 Hz, 1 H)
The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CALLAHAN, James Francis; COLANDREA, Vincent J.; COOPER, Anthony William James; GOODWIN, Nicole Cathleen; HUFF, Chelsea Ariane; KARPIAK, Joel; KERNS, Jeffrey K.; NIE, Hong; (404 pag.)WO2018/109647; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem