184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Production Example 152 (0472) 5-(Naphthalen-1-ylmethyl)isoxazole-3-carboxylic acid (123 mg, 0.49 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (123 mg, 0.90mmol), triethylamine (0.23 mL, 1.66 mmol) and 1-hydroxybenzotriazole (9 mg, 0.06 mmol) were added to chloroform (amylene addition product) (5 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (159mg, 0.83 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 95 mg of N-(tetrahydrofuran-3-ylmethyl)-5-(naphthalen-1-ylmethyl)iso xazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (160)) represented by the following formula. 1H-NMR (CDCl3, TMS, delta(ppm)):1.57-1.67(m, 1H), 1.99-2.08(m, 1H), 2.48-2.60(m, 1H), 3.36-3.44(m, 2H), 3.52-3.57(m, 1H), 3.69-3.93(m, 3H), 4.55(s, 2H), 6.27(s, 1H), 6.96(brs, 1H), 7.37-7.54(m, 4H), 7.80-7.85(m, 1H), 7.86-7.92(m, 2H), 184950-35-4
The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
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