165253-29-2, 3-(Bromomethyl)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Intermediate 16: 2-Butoxy-8-methoxy-9-(tetrahvdrofuran-3-ylmethyl)-9H-purin-6- amine2-Butoxy-8-methoxy-9H-purin-6-amine trifluoroacetate salt (0.2Og) was dissolved in anhydrous N,N-dimethylformamide (5 ml.) was treated with anhydrous potassium carbonate (0.315 g), heated to 600C for 1 hour and then cooled to room temperature. To the above was added 3-(bromomethyl)tetrahydrofuran (0.103 g) and the reaction mixture heated at 500C, overnight. The reaction mixture was quenched with water (25 ml.) and extracted into ethyl acetate (3 times, 100 ml. combined total volume). The combined organic phase was separated and passed through a hydrophobic frit to dry. The organic phase was stripped to give a gum which was purified by Ci8 reverse phase chromatography using water (containing 0.1percent formic acid)-acetonitrile (containing 0.05percent formic acid) as eluant (20-60percent) to afford the title compound as a white solid (97mg). MS calcd for (Ci5H23N5Os)+ = 321 MS found (electrospray): (M+H)+ = 3221 H NMR (CDCI3): 5.39 (2H, s), 4.24 (2H, t), 4.08 (3H, s), 3.96-3.85 (3H, overlapping m), 3.71 (2H, m), 3.60 (1 H, m), 2.81 (1 H, m), 1.93 (1 H, m), 1.76-1.63 (3H, overlapping m), 1.46 (2H, m), 0.93 (3H, t)., 165253-29-2
The synthetic route of 165253-29-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/101867; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem