87219-29-2, (S)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
87219-29-2, In a 500 ml round-bottomed flask phenylmethyl [(3S)-5-oxotetrahydro-3-furanyl]carbamate (4.3 g, 18.28 mmol, available from Sigma -Aldrich No. 419249) was dissolved in water (100 ml) and acetone (100 ml) and to this solution CS2CO3 (10.72 g, 32.9 mmol) was added and the reaction left under stirring at room temperature for 5 hours. The solution was then transferred into a separatory funnel and washed with EtOAc (2 x 50 ml). The aqueous phase was then acidified to pH = 2 by the addition of a 2 M HCl aqueous solution and then extracted with EtOAc (5 x 100 mis). The organic phase was dried (Na2SO4) and solvent removed under reduced pressure to give the title compound Dl (3.78 g) as a white solid. MS: (ES/+) m/z: 254 (M+l). C12H15NO5 requires 253. 1H NMR (400 MHz, DMSO-J6) delta (ppm): 12.11 (bs, 1 H), 7.41-7.07 (m, 5 H), 5.17-4.92 (m, 2 H), 3.95-3.62 (m, 1 H), 3.42- 3.22 (m, 2 H), 2.55-2.40 (m, 1 H), 2.34-2.23 (m, 1 H)
The synthetic route of 87219-29-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David; CASTIGLIONI, Emiliano; DI FABIO, Romano; PAVONE, Francesca; WO2010/63662; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem