With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14631-43-7,2-Cyanotetrahydrofuran,as a common compound, the synthetic route is as follows.
14631-43-7, Preparation c-130 2-{6-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonitrile Sodium bis(trimethylsilyl)amide (1.8 mL, 1.79 mmol) was added to a solution of tetrahydro-furan-2-carbonitrile (0.17 g, 1.79 mmol) in anhydrous tetrahydrofuran (6 mL) under an atmosphere of nitrogen at -78 C. The resulting yellow solution was stirred for 50 minutes, and then a solution of 5-iodomethyl-2-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridine (0.25 g, 0.596 mmol) in anhydrous tetrahydrofuran (3 mL) was added to the enolate solution. The mixture was stirred at -78 C. for 1.5 hours, and quenched with saturated aqueous ammonium chloride (5 mL). The aqueous phase was extracted with ethyl acetate (3*50 mL), and the combined organic extracts washed with water (30 mL), dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (7% to 45% ethyl acetate/hexanes) to afford the title compound (0.11 g, 46%) as a white solid. LRMS (m/z): 390 (M+H)+. 1H NMR (CDCl3, 300 MHz), delta 8.03 (1H, d, J=2.5 Hz), 7.96 (2H, m), 7.56 (1H, dd, J=8.5, 2.5 Hz), 7.40 (3H, m), 6.68 (1H, d, J=8.5 Hz), 4.54 (2H, m), 3.96 (2H, m), 3.00 (4H, m), 2.33 (5H, d, J=3.2 Hz), 1.92 (2H, m).
As the paragraph descriping shows that 14631-43-7 is playing an increasingly important role.
Reference£º
Patent; Pfizer Inc; US2005/187266; (2005); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem