With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0
As shown in FIG. 3, a desamination reaction (second reaction) of homoserine lactone hydrochloride using water as a solvent was carried out.A portion of the upper layer recovered in the first reaction (80.2 mL)And 120 g of HSL ¡¤ HCl were placed in a reactor and reacted while injecting NO / Air (O 2) gas at room temperature (25 C.) and atmospheric pressure (1 atm). GC analysis was performed to confirm the presence of unreacted HSL ¡¤ HCl, and the product was placed in a separating funnel and allowed to stand until it was separated.64.04 g of the bottom layer was recovered from the layered solution and the recovered bottom layer was evaporated under reduced pressure (2-4 torr) to 50 & lt; 0 & gt; C to recover 58.28 g of product. As a result of analyzing the components of the product, Cl-GBL contained 91.34%, HO-GBL contained 5.04%, and furanone contained 2.62%.After separating the lower layer, the upper layer was 154.05 g, and 80 mL (94.25 g) was used as a solvent for the tertiary reaction. The residue (59.8 g) was extracted three times with chloroform (60 mL / 60 mL / 60 mL) and the combined extracts were evaporated under reduced pressure to recover 18.57 g of product. As a result of analyzing the components of the product, 87.36% of Cl-GBL, 4.11% of HO-GBL and 7.37% of furanone were contained.After the chloroform extraction, the solvent was evaporated under reduced pressure to recover 7.8 g of the product. As a result of analyzing the components of the product, Cl-GBL was contained in 2.28%, HO-GBL in 91.44%, and furanone in 0.92%.
42417-39-0 3-Aminodihydrofuran-2(3H)-one hydrochloride 445963, aTetrahydrofurans compound, is more and more widely used in various.
Reference£º
Patent; CJ CHEILJEDANG CORPORATION; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; YANG, YOUNG RYEOL; KIM, BYUNG SIK; KIM, JEONG HYUN; LEE, JUNG HO; SHIN, HYUN KWAN; KIM, JU NAM; CHO, KYUNG HO; (40 pag.)KR2015/118287; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem