With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.,184950-35-4
Production Example 125 (0441) 5-[(1-Benzyloxy-1-phenylmethyl]isoxazole-3-carboxylic acid (0.44 g, 1.4 mmol), tetrahydrofuran-3-ylmethylamine hydrochloride (0.23 g, 1.7 mmol), triethylamine (0.17 g, 1.7 mmol) and 1-hydroxybenzotriazole (0.02 g, 0.17 mmol) were added to chloroform (amylene addition product) (4 mL). 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (0.32 g, 1.7 mmol) was added to the mixture at room temperature, and the mixture was stirred overnight and then concentrated under reduced pressure. Dilute hydrochloric acid was added to the concentrate, and the mixture was extracted twice with ethyl acetate. The organic layer was washed with saturated saline water, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was applied to a silica gel column chromatography to obtain 0.45 g of N-(tetrahydrofuran-3-ylmethyl)-5-[(1-benzyloxy-1-phenylmeth yl]isoxazole-3-carboxamide (hereinafter, referred to as Compound of Present Invention (130)) represented by the following formula. 1H-NMR(CDCl3, TMS, delta(ppm)):1.63-1.68(1H, m), 2.02-2.11(1H, m), 2.55-2.56(1H, m), 3.42-3.46(2H, m), 3.57(1H, dd), 3.75(1H, dd), 3.84(1H, dd), 3.89-3.91(1H, m), 4.60(2H, dd), 5.57(1H, s), 6.62(1H, s), 6.91(1H, s), 7.32-7.44(10H, m)
The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Chemical Company, Limited; MITSUDERA, Hiromasa; AWASAGUCHI, Kenichiro; AWANO, Tomotsugu; UJIHARA, Kazuya; EP2952096; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem