With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.165253-29-2,3-(Bromomethyl)tetrahydrofuran,as a common compound, the synthetic route is as follows.,165253-29-2
Example 426] (1695) (1696) To the solution of 56 mg of tert-butyl 2-((1H-indol-4-yl)amino)-5-cyclopropylnicotinate in 2 mL of N,N-dimethylformamide, 22 mg of potassium tert-butoxide and 33 mg of 3-(bromomethyl)tetrahydrofuran were added, and the resultant was stirred for one hour and then allowed to stand overnight. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (gradient elution with hexane:ethyl acetate = 100:0-67:33) to give tert-butyl 5-cyclopropyl-2-((1-((tetrahydrofuran-3-yl)methyl)-1H-indol-4-yl)amino)nicotinate as a yellow oil. MS (ESI, m/z): 434 (M+H)+.
The synthetic route of 165253-29-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Toyama Chemical Co., Ltd.; FUJIFILM Corporation; TANAKA, Tadashi; KONISHI, Yoshitake; KUBO, Daisuke; FUJINO, Masataka; DOI, Issei; NAKAGAWA, Daisuke; MURAKAMI, Tatsuya; YAMAKAWA, Takayuki; EP2915804; (2015); A1;,
Tetrahydrofuran – Wikipedia
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