With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.,453-20-3
To a solution of tetrahydro-furan-3-ol (9.0 g, 79 mmol) and triethyl amine (20 mL, 176 mmol) in THF (200 mL) was added methanesulfonyl chloride (12.9 g, 1 13 mmol) at 0C. The mixture was stirred overnight and then evaporated to dryness. The residue was extracted with EtOAc (3 x 300 mL) and washed with saturated, aqueous NaHC03. The organic layer was dried over Na2S04 and evaporated to dryness to give methanesulfonic acid tetrahydro-furan-3-yl ester as a yellow viscous liquid (12.4 g, 94%) which was used without further purification.
The synthetic route of 453-20-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; H. LUNDBECK A/S; ESKILDSEN, J¡ãrgen; WO2014/49133; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem