5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5061-21-2
General procedure: Anhydrous K2CO3 (1 equiv.) was added to the solution of relevant amine (1 equiv.) in 20 mL of solvent (acetonitrile, DCM or Me2CO) and the mixture was stirred at room temperature for 0.5 h. Then a solution of 3-bromodihydrofuran-2(3H)-one (1 equiv.) in 5 mL of appropriate solvent was added dropwise and stirring was continued for 3-20 h. In the synthesis of compounds 11 and 12 tetrabutylammonium bromide (TBAB) (0.1 equiv.) was added. After the reaction was completed, the precipitate was filtered off and the filtrate was concentrated under vacuum. Obtained crude products were recrystallized from suitable solvent (solid) or purified by column chromatography (oil). Lactone 11 was isolated as a hydrochloride salt and recrystallized from DCM. Synthesis of compound 13 was described elsewhere [24] B. Malawska and S. Gobaille, Pharmazie 50 (1995), pp. 390-393. View Record in Scopus | Cited By in Scopus (10)[24].
The synthetic route of 5061-21-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kulig, Katarzyna; Wickowski, Krzysztof; Wickowska, Anna; Gajda, Justyna; Pochwat, Bart?omiej; Hoefner, Georg C.; Wanner, Klaus T.; Malawska, Barbara; European Journal of Medicinal Chemistry; vol. 46; 1; (2011); p. 183 – 190;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem