With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.
3-hydroxytetrahydrofuran (869.00 jiL, 10.56 mmol) was diluted in THF (33.5 mL). Then, the solution was cooled to 0 C and LiHMDS (10.00 mL, 10.56 mmol) was added. After 30 mi 2-fluoro-3-nitropyridine (1.50 g, 10.56 mmol) was quickly added and the reaction mixture was stirred overnight allowing the temperature to reach rt. Thereaction mixture was mixed with another batch (from 100 mg of 2-fluoro-3- nitropyridine) and partitioned between water and EtOAc. The organic layer was separated, dried over MgSO4, filtered and concentrated to afford 2.03 g of intermediate 54 (91% yield) which was directly engaged in the next steps without any further treatment.
As the paragraph descriping shows that 453-20-3 is playing an increasingly important role.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; STANSFIELD, Ian; QUEROLLE, Olivier Alexis Georges; GROSS, Gerhard Max; JACOBY, Edgar; MEERPOEL, Lieven; KULAGOWSKI, Janusz Jozef; MACLEOD, Calum; MANN, Samuel Edward; GREEN, Simon Richard; HYND, George; (476 pag.)WO2017/125534; (2017); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem