88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5-fluoro-4-[4-methyl-5-oxo-3-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]-2-{[(2S)-4-methylpentan-2-yl]oxy}benzoic acid (Intermediate 82, 150 mg, 395 muiotaetaomicronIota) and tetrahydrofuran-3-amine (44.0 mg, 505 muiotaetaomicronIota) were dissolved in dichloromethane (20 mL). Triethylamine (167 muIota_, 1 .2 mmol) was added, followed by HATU (190 mg, 499 muiotaetaomicronIota). The mixture was stirred at room temperature overnight. The solvent was removed and the mixture was purified using preparative TLC to yield 66mg of desired product (37percent yield).
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Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; THE BROAD INSTITUTE, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION; GRADL, Stefan, Nikolaus; NGUYEN, Duy; EIS, Knut; GUeNTHER, Judith; STELLFELD, Timo; JANZER, Andreas; CHRISTIAN, Sven; MUELLER, Thomas; EL SHEIKH, Sherif; ZHOU, Han, Jie; ZHAO, Changjia; SYKES, David, B; FERRARA, Steven, James; LIU, Kery; KROeBER, Michael; MERZ, Claudia; NIEHUES, Michael; SCHAeFER, Martina; ZIMMERMANN, Katja; NISING, Carl, Friedrich; (509 pag.)WO2018/77923; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem