Day: August 26, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873063-62-8,(R)-3-Iodotetrahydrofuran,as a common compound, the synthetic route is as follows.

[0388] N-(3′-Fluoro-5,6′-dimethyl-2,2′-bipyridin-4-yl)-2H-pyrazolo[4,3-b]pyridin-7-amine (43 mg, 0.129 mmol) was dissolved in DMF (2 mL), cooled to 0C and sodium hydride (4.75 mg, 60%), 0.129 mmol) was added. The reaction mixture was stirred for 5 minutes and (R)-3-iodotetrahydrofuran (25.5 mg, 0.129 mmol) was added and further stirred for 5 minutes at room temperature and then heated in a microwave at 65C for 40 minutes. The reaction mixture was then cooled, concentrated in vacuo to give a residue which was combined with MeOH and filtered. The filtrate was purified by preparative HPLC using a Sunfire Prep 5muiotaeta CI 8, 75 X 30 mm column 5 muiotaeta CI 8, 75 X 30 mm column eluting with a gradient of 5-30% acetonitrile (containing 0.035% TFA) in water (containing 0.05% TFA) to give the title compounds as TFA salts: (S)-N-(3′-fluoro-5,6′-dimethyl-2,2′-bipyridin-4-yl)- l-(tetrahydrofuran-3-yl)-lH-pyrazolo[4,3-b]pyridin-7-amine 1H NMR (400 MHz,CHLOROFORM- ) delta ppm 1.27 – 1.42 (m, 1 H) 2.36 – 2.39 (m, 4 H) 2.39 – 2.51 (m, 2 H) 2.55 (s, 3 H) 3.80 – 3.89 (m, 1 H) 4.01 (dd, J=9.85, 7.33 Hz, 1 H) 4.11 – 4.22 (m, 2 H) 7.01 (d, J=3.54 Hz, 1 H) 7.14 (dd, J=8.46, 3.41 Hz, 1 H) 7.31 – 7.44 (m, 2 H) 8.25 (s, 1 H) 8.41 (br. s., 1 H), MS [M+H] found 405.4; and (S)-N-(3*-fluoro-5,6*-dimethyl-2,2,-bipyridin-4-yl)- l-(tetrahydrofuran-3-yl)-lH-pyrazolo[4,3-b]pyridin-7-amine 1H NMR (400 MHz,CHLOROFORM-;/) delta ppm 2.44 (s, 3 H) 2.46 – 2.56 (m, 1 H) 2.57 – 2.70 (m, 4 H) 4.04 (td, J=8.59, 5.56 Hz, 1 H) 4.18 – 4.31 (m, 3 H) 5.22 – 5.33 (m, 1 H) 7.02 (d, J=5.05 Hz, 1 H) 7.13 – 7.23 (m, 2 H) 7.43 (dd, J=10.48, 8.46 Hz, 1 H) 8.13 (d, J=1.26 Hz, 1 H) 8.26 (s, 1 H) 8.41 (d, J=5.05 Hz, 1 H) 8.62 (s, 1 H), MS [M+H] found 405.4.

The synthetic route of 873063-62-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KWOK, Lily; LARSON, John David; SABAT, Mark; WO2011/146287; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (2,5-difluorobenzyloxymethyl) isoxazole-3-carboxylic acid (0.54 g, 2.0 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.41 g, 3.0 mmol), Triethylamine (0.30 g, 3.0 mmol) And 1 – hydroxybenzotriazole (0.03 g, 0.2 mmol) Was added to chloroform (amylen added product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.46 g, 2.4 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution , Washed with saturated brine, After drying with anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (2,5-difluorobenzyloxymethyl) isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (259)) 0.17 g was obtained.

As the paragraph descriping shows that 184950-35-4 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

42417-39-0, 3-Aminodihydrofuran-2(3H)-one hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4-(5-(substituted phenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (0.53mmol)in 10mL DCM was added methyl glycinate hydrochloride (0.80mmol), acetic acid (2.12mmol), and N,N-diisopropylethylamine (0.80mmol), and 10mL MeOH. After the reaction was stirred for 3h, sodium cyanoborohydride (0.53mmol) was added. The reaction mixture was quenched with saturated aqueous NaHCO3 solution and extracted with DCM. The combined organic layers were washed with brine, dried over Na2SO4, then filtered and concentrated. The residue was purified by silica gel flash column chromatography (DCM:MeOH=20:1) to afford compound 15-1a?15-3n (except for 15-1l).

The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Tianqi; Jin, Jing; Chen, Yonghui; Xi, Qiumu; Hu, Jinping; Jia, Wenqiang; Chen, Xiaoguang; Li, Yan; Wang, Xiaojian; Yin, Dali; Bioorganic Chemistry; vol. 82; (2019); p. 41 – 57;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.

3-bromo-7-(4-methoxybenzyl)-6-methylimidazo[1,5-a]pyrazin-8(7H)-one (60 mg, 0.172 mmol) and tetrahydrofuran-3-amine (0.04 ml, 0.465 mmol) were mixed in NMP (2 mL) and DIPEA (0.23 ml, 1.317 mmol). The reaction was heated for 4 hours at 250¡ãC in the microwave oven. The reaction was purified on silica gel, via preparative LC-MS, and preparative TLC (10percent EtOH in ethyl acetate) to give 7-(4-methoxybenzyl)-6-methyl-3-((tetrahydrofuran-3- yl)amino)imidazo[1,5-a]pyrazin-8(7H)-one (2 mg, 0.005 mmol) in 3percent yield. 1H NMR (600 MHz, Dimehtyisulfoxide-d6) delta 8.50 (m, NH), 7.68 (s, 1 H), 7.31 (s, 1 H) 7.22 (d, J = 7.1 Hz, 2H), 6.88 (d, J = 7.1 Hz, 2H), 4.87 (m, 1 H), 4.35 (d, J = 14 Hz, 2H), 4.11 (m, 1 H), 4.02 (m, 1 H), 3.92 (m, 1 H), 3.86 (m, 1 H), 3.71 (s, 3H), 2.60 (m, 1 H), 2.5 (m, 1 H) 2.31 (s, 3H). LC-MS: tR = 0.54 min (method 19), m/z = 355.2 [M + H]+.

As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.

Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (157 pag.)WO2018/78038; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

5061-21-2, 2-Bromo-4-butanolide is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step a: Preparation of 3-[(4-nitrophenyl)sulfanyl]dihydrofuran-2(3H)-oneTo an ice-cooled solution ofp-nitro thiophenol (10.0 g, 0.0645 moles) in dichloromethane (75 mL) under argon atmosphere were added triethylamine (19.4 g, 0.1935 moles) and a solution of bromo-lactone (11.1 g, 0.067 moles) in dichloromethane (75 mL) drop wise. The reaction mixture was allowed to stir for about 30 minutes at room temperature. After completion, reaction mixture was diluted with water and extracted in dichloromethane. The combined organic layer was dried over anhydrous sodium sulphate and concentrated to get a crude product. The crude product so obtained was purified by silica gel column using 30% ethyl acetate in hexane as eluent to get title compound.Yield: 11 g

The synthetic route of 5061-21-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; KHERA, Manoj Kumar; SATTIGERI, Jitendra; YADAV, Neeraj Kumar; RAUF, Abdul Rehman Abdul; CLIFFE, Ian A.; BHATNAGAR, Pradip Kumar; RAY, Abhijit; SRIVASTAVA, Punit; DASTIDAR, Sunanda Ghosh; WO2012/38943; (2012); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5- (4-bromo-3-fluorobenzyloxymethyl) isoxazole-3-carboxylic acid (1.42 g, 4.3 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (0.89 g, 6.5 mmol), Triethylamine (0.90 mL, 6.5 mmol) And 1-hydroxybenzotriazole (0.06 g, 0.4 mmol) Was added to chloroform (amylene added product) (10 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (0.99 g, 5.2 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. Dilute hydrochloric acid was added to the residue, And extracted three times with ethyl acetate. The organic layer was washed with saturated aqueous sodium hydrogen carbonate solution, Wash with saturated brine , Dried over anhydrous sodium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, The following equation Indicated by N- (tetrahydrofuran-3-ylmethyl) -5- (4-bromo-3-fluorobenzyloxymethyl) isoxazole-3-carboxamide (Hereinafter referred to as this amide compound (272)) 0.59 g was obtained.

The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.

DIPEA (1 .93ml, 1 1 .1 mmol) was added to a solution of Tricyclo[3.3.1.13,7]decane-1 – carbonyl chloride (1 ) (2g, 10.1 mmol) and 3-aminotetrahydrofuran; (29)(1 .0ml, 1 1 mmol) in DCM (20ml) and the solution stirred at room temperature for 4 hours. The solution was washed with 0.1 N HCI (30ml), saturated NaHC03 (30ml), dried (Na2S04), filtered and the solvents removed to give crude product which was further purified via crystallization from 15percent EA in hexanes to give as a white solid

The synthetic route of 88675-24-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; UNILEVER PLC; UNILEVER N.V.; CONOPCO, INC., D/B/A UNILEVER; AU, Van; HARICHIAN, Bijan; CLOUDSDALE, Ian Stuart; BAJOR, John Steven; DICKSON, Jr, John Kenneth; WO2014/139965; (2014); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

2399-48-6, (Tetrahydrofuran-2-yl)methyl acrylate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a 0.52 mL microwave vial were added TPT-MeOH (100 mg, 0.30 mmol),n-BuA (0.43 mL, 3.0 mmol), and 1,4-dioxane (1.2 mL), and then the vial was sealed. The mixture was stirred and heated at 140 C under microwave irradiation for 2 h. The Kugelrohr distillation under reduced pressure (1 mmHg, 200 C) gave the product (Entry 16, 259 mg, 69% yield) as a transparent liquid.

As the paragraph descriping shows that 2399-48-6 is playing an increasingly important role.

Reference£º
Article; Matsuoka, Shin-Ichi; Nakazawa, Masanori; Suzuki, Masato; Bulletin of the Chemical Society of Japan; vol. 88; 8; (2015); p. 1093 – 1099;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.86087-23-2,(S)-(+)-3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.

To a a solution of (S)-(+)-3-hydroxytetrahydrofuran (0.50 g, 5.7 mmol) in methylene chloride (50 mL) was added triphenylphosphine (3.0 g, 11 mmol), 1H-imidazole (0.75 g, 11 mmol), and iodine (2.9 g, 11 mmol) sequentially. After being refluxed under N2 overnight, the reaction was quenched with 0.2 M Na2S2O3 (60 mL). The organic layer was separated and the aqueous layer was extracted with methylene chloride three times. The combined organics were dried (MgSO4), filtered, and concentrated to give a wet, yellow solid. To the solids was added pentane (100 mL) and stirred for 2 hours. The solids were filtered off and the filtrate was concentrated to give the desired product (970 mg, 79.4%) as yellow oil. 1H NMR (CDCl3) delta 4.30-3.85 (5H, m), 2.50-2.20 (2H, m).

86087-23-2 (S)-(+)-3-Hydroxytetrahydrofuran 2733227, aTetrahydrofurans compound, is more and more widely used in various.

Reference£º
Patent; Xue, Chu-Biao; Zheng, Changsheng; Feng, Hao; Xia, Michael; Glenn, Joseph; Cao, Ganfeng.; Metcalf, Brian W.; US2006/4018; (2006); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53662-85-4,Methyl tetrahydrofuran-3-carboxylate,as a common compound, the synthetic route is as follows.

Intermediate 4: 3-Oxo-3-(tetrahydro-furan-3-yl)-propionic acid ethyl ester To a solution of lithium bis(trimethylsilyl)amide (1 M in hexanes; 100 mL) in THF (200 mL) at -78 C. was added dry ethyl acetate (10.8 g, 12 mL, 122.5 mmol) dropwise. After 30 min at -78 C., the mixture was treated with a solution of tetrahydro-furan-3-carboxylic acid methyl ester (6.0 g, 46.1 mmol) in THF (50 mL). After 4 h at -78 C., the reaction was quenched with satd. aq. NH4Cl, warmed to rt, and extracted with EtOAc (5*75 mL). The combined organic layers were washed with satd. aq. NaCl, dried, and concentrated to give a colorless oil. Chromatography on SiO2 (EtOAc/CH2Cl2) afforded the title compound (3.3 g).

As the paragraph descriping shows that 53662-85-4 is playing an increasingly important role.

Reference£º
Patent; Cai, Hui; Chavez, Frank; Edwards, James P.; Fitzgerald, Anne E.; Liu, Jing; Mani, Neelakandha S.; Neff, Danielle K.; Rizzolio, Michele C.; Savall, Brad M.; Smith, Deborah M.; Venable, Jennifer D.; Wei, Jianmei; Wolin, Ronald L.; US2008/194577; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem