With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22929-52-8,Dihydrofuran-3(2H)-one,as a common compound, the synthetic route is as follows.
A. Methyl magnesium iodide (3.0M in Et2 O, 20 mL) was added to a solution of tetrahydrofuran-3-one (1.6 g, 18.6 mmol) in 15 mL of Et2 O at 0¡ã C. After stirring 4 h at 0¡ã C. the mixture was quenched with sat. aq. NH4 Cl solution and extracted with Et2 O. The combined extracts were dried over MgSO4 and concentrated under reduced pressure to give the crude material. Purification by chromatography (CH2 Cl2 to 1percent MeOH/CH2 Cl2 to 2percent MeOH/CH2 Cl2) gave 3-hydroxy-3-methyltetrahydrofuran (0.290 g). 1 H NMR consistent with structure.
As the paragraph descriping shows that 22929-52-8 is playing an increasingly important role.
Reference£º
Patent; Vertex Pharmaceuticals Incorporated; US5691372; (1997); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem