With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10374-51-3,5-(Hydroxymethyl)dihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.
In a reactor with a well ventilated system,8 g (0.07 mol) of beta-hydroxymethyl-gamma-butyrolactone was added to 50 mL of chloroform, and 1 g of phosphorus trichloride, The air in the reactor was replaced with nitrogen,And then slowly into the reaction solution into the chlorine, at room temperature and light conditions for 3h,The solvent was removed and purified by column chromatography3-chloro-5- (hydroxymethyl) tetrahydrofuran-2 (3H) -one.
The synthetic route of 10374-51-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Henan Normal University; Jiang Tao; Mao Longfei; Li Qing; Hao Yuwei; Wang Zhenzhen; Wu Xiaoxia; Xu Shaojie; (12 pag.)CN106632285; (2017); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem