With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19311-37-6,3-Bromotetrahydrofuran,as a common compound, the synthetic route is as follows.
[00494] To a solution of 119-1 (50 mg, 0.16 mmol, 1.00 eq) and 119-2 (32.2 mg, 0.21 mmol, 1.30 eq) in DMF (3 mL) was added K2C03 (45.3 mg, 0.33 mmol, 2.00 eq). The reaction was heated to 100C for 16 hr. LCMS showed that -80% of desired MS signal was detected. The reaction was diluted with EtOAc (20 mL) and washed with brine (2* 10 mL). The organic layer was dried over Na2S04 and concentrated. The crude product was purified by Prep.HPLC (acidic conditions) to give the title compound (17.36 mg, 46.25 umol, 28.24% yield). 1HNMR and LCMS confirmed that the desired product was obtained. LCMS (ESI): RT = 0.910 min, mass calc. for Ci8Hi6F3N50 375.13, m/z found 376.0[M+H]+; 1HNMR (400 MHz, CDC13) 9.05 (s, 1H), 8.21 (dd, J= 8.0, 1.6 Hz, 1H), 7.60 – 7.50 (m, 3H), 7.40 – 7.35 (m, 1H), 7.29 (d, J= 8.4 Hz, 2H), 7.05 (t, J= 8.0 Hz, 1H), 5.65- 5.50 (m, 1H), 4.40 – 4.25 (m, 3H), 4.15- 4.00 (m, 1H), 2.80 – 2.65 (m, 1H), 2.65- 2.50 (m, 1H).
19311-37-6 3-Bromotetrahydrofuran 12929516, aTetrahydrofurans compound, is more and more widely used in various.
Reference£º
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (396 pag.)WO2018/204532; (2018); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem