88675-24-5, Tetrahydrofuran-3-amine is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound TDI01113-4 (200 mg, 0.52 mmol) and tetrahydrofuran-3-amine (54.6 mg, 0.62 mmol) were dissolvedin N,N-dimethylformamide (10 mL), HATU (236 mg, 0.62 mmol) and diisopropylethylamine (268 mg, 2.08 mmol) wereadded, and the reaction was performed at room temperature overnight. Thin layer chromatography (dichloromethane/methanol =10:1) indicated the reaction was complete. Water (60 mL) was slowly added to the reaction solution, a largeamount of solid precipitated and was filtered after being stirred for 30 minutes. The solid was purified by high-performanceliquid chromatography to afford compound TDI01113 (56.2 mg, yellow solid, yield: 23.7percent).1H NMR (400 MHz, DMSO-d6) delta 13.05 (s, 1H), 9.67 (s, 1H), 8.93 (s, 1H), 8.90 (d, J = 6.4 Hz, 1H), 8.42 (dd, J = 8.4, 1.2Hz, 1H), 8.39 (d, J = 6.0 Hz, 1H), 8.23 (s, 1H), 8.18 (s, 1H), 8.10 (s, 1H), 8.06 (d, J = 8.4 Hz, 1H), 7.59 (s, 2H), 6.71 (d,J = 6.0 Hz, 1H), 4.51 – 4.45 (m, 1H), 3.91 – 3.85 (m, 2H), 3.77 – 3.71 (m, 1H), 3.66 – 3.63 (m, 1H), 2.24 – 2.15 (m, 1H),1.99 – 1.92 (m, 1H). MS m/z (ESI): 457.0 [M+H].
As the paragraph descriping shows that 88675-24-5 is playing an increasingly important role.
Reference£º
Patent; Beijing Tide Pharmaceutical Co., Ltd.; Zhao, Yanping; Wang, Hongjun; Li, Gong; Jiang, Yuanyuan; Li, Xiang; Zhou, Liying; Liu, Yanan; (235 pag.)EP3421465; (2019); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem