With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2399-48-6,(Tetrahydrofuran-2-yl)methyl acrylate,as a common compound, the synthetic route is as follows.
To the 20 mL reaction tube was added 112 mg (0.5 mmol) of compound dibenzoylmethane, 7 mg (0.025 mmol) of K2CO3, 147 muL (1 mmol) of tetrahydrofurfural acrylate and 0.5 mL of tetrahydrofurfuryl alcohol at a temperature of 85 C The reaction was stirred for 24 hours and cooled to room temperature (18-25 C) and transferred to a small flask of 10 mL. The solvent was distilled off under reduced pressure and then passed through a column of neutral alumina. The developing solvent used was petroleum ether: ethyl acetate= 13: 1 to 4: 1 to give compound III-16 126 mg in 91% yield
The synthetic route of 2399-48-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Southwest University; Cai Guixin; Wen Jing; (13 pag.)CN105061125; (2017); B;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem