453-20-3, 3-Hydroxytetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
3-Hydroxytetrahydrofuran (83.3 muL, 1.03 mmol) was dissolved in methylene chloride(anhydrous, 2 mL) and cooled to 0 0C followed by the addition of triethylamine (166 muL, 1.2 mmol) and methanesulfonyl chloride (88 muL, 1.14 mmol). The reaction mixture was stirred for 16 h while gradually warming to ambient temperature. The reaction was quenched with water, diluted with methylene chloride (20 mL), and the resulting layers were separated. The organic layer was washed with water (2 x 2 mL) and the combined aqueous phases were extracted with methylene chloride (2 x 3 mL). The combined organic phases were washed with brine (2 x 2 mL), dried over Na2SOzI, filtered, and concentrated. The crude product was used directly in the next step.
The synthetic route of 453-20-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; INCYTE CORPORATION; ZHUO, Jincong; METCALF, Brian; WO2008/64157; (2008); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem