With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.165253-29-2,3-(Bromomethyl)tetrahydrofuran,as a common compound, the synthetic route is as follows.
Potassium carbonate (60.1 mg) was added to a mixture of 2-(4-chlorophenyl)-5-(4-hydroxy-3-methoxyphenyl)furo[3,2-c]pyridin-4(5H)-one (80 mg), 3-(bromomethyl)tetrahydrofuran (53.8 mg) and DMF (1.5 mL) at room temperature, and the mixture was stirred at 80¡ãC for 2 hr. To the resulting mixture was dropwise added brine, and the mixture was extracted with ethyl acetate. The resulting organic layer was dried over magnesium sulfate and concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (ethyl acetate/hexane), and the solid was recrystallized from ethanol to give the title compound (35.8 mg) as a white solid. 1H NMR (400 MHz, CHLOROFORM-d) delta 1.70-1.87 (1H, m), 2.02-2.21 (1H, m), 2.67-2.97 (1H, m), 3.71-3.84 (2H, m), 3.85-3.89 (3H, m), 3.90-4.05 (4H, m), 6.64 (1H, d, J = 7.5 Hz), 6.81-7.03 (3H, m), 7.16-7.33 (2H, m), 7.42 (2H, d, J = 8.4 Hz), 7.71 (2H, d, J = 8.5 Hz). MS (ESI+):[M+H]+ 452.1.
As the paragraph descriping shows that 165253-29-2 is playing an increasingly important role.
Reference£º
Patent; Takeda Pharmaceutical Company Limited; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; KINA, Asato; EP2848622; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem