17347-61-4, 2,2-Dimethylsuccinicanhydride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A stirring solution of compound 24-1 (55 mg, 0.10 mmol), DMAP (14.8 mg, 0.12 mmol) and 2,2-dimethylsuccinic anhydride (38.7 mg, 0.30 mmol) in dry pyridine (1.0 mL) is heated at 120¡ã C. for 4 hours.Another 0.30 mmol of 2,2-dimethylsuccinic anhydride is added and heating at 120¡ã C. is continued for 24 hours.The mixture is cooled down to room temperature and concentrated to dryness.The residue is diluted in ethyl acetate, washed twice with HCl 1N, water and brine, dried over sodium sulfate and concentrated to dryness.The residue is purified by flash column chromatography on silica gel (methanol/DCM 0percent to 10percent) to yield the title compound 19-2 as a white solid (48 mg, 71percent).1H NMR (400 MHz, CDCl3): delta [ppm] 7.71 (m, 2H), 7.50 (m, 1H), 7.42 (m, 2H), 6.11 (s, 1H), 4.48 (d*d, 1H), 3.17 (m, 1H), 2.90 (d, 1H), 2.83 (d, 1H), 2.66 (d, 1H), 2.55 (d, 1H), 2.41 (d, 1H), 2.36 (d, 1H), 1.95 (m, 3H), 1.76-1.16 (m, 26H), 1.13 (s, 3H), 0.97 (s, 3H), 0.87 (s, 3H), 0.83 (s, 3H), 0.79 (s, 3H).LC/MS: m/z=674.70 (M+H*).
The synthetic route of 17347-61-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Moinet, Christophe; Halab, Liliane; Turcotte, Nathalie; Bubenik, Monica; Courchesne, Marc; Poisson, Carl; Pereira, Oswy Z.; Nguyen-Ba, Paul; Liu, Bingcan; Chauret, Nathalie; Cadilhac, Caroline; Kong, Laval Chan Chun; US2011/77227; (2011); A1;,
Tetrahydrofuran – Wikipedia
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