915095-89-5, (S)-3-(4-(5-Bromo-2-chlorobenzyl)phenoxy)tetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add Compound C-2 (10 g, 27.2 mmol) to a 250 mL three-necked flaskAnd 70mL of tetrahydrofuran, stir and dissolve.The resulting solution is cooled to -70 to -80 C,Slowly add n-butyllithium solution (2.5M THF solution) to the cooled solution.12.5 mL, 1.15 eq), and stirred at -70 to -80 C for 1 hour.Further, a solution of the compound B in tetrahydrofuran (8.5 g of B in 30 mL of tetrahydrofuran, 31.3 mmol, 1.15 eq) was added dropwise to the reaction mixture.The mixture was stirred at -70 to -80 C for 2 hours. The reaction solution is heated to -10 to 0 C.The reaction solution was diluted with a saturated aqueous solution of NH 4Cl (20 mL).Add ethyl acetate(100 mL ¡Á 2) The reaction quenching solution was extracted twice, and the ethyl acetate layer was combined.The organic layer was washed with saturated brine (100 mL).The organic layer was concentrated to dryness under reduced pressure at 40 to 50 C.The resulting solid was recrystallized from ethyl acetate and n-hexane.Having 11.4g of compoundD-2, yield 88.4%.
As the paragraph descriping shows that 915095-89-5 is playing an increasingly important role.
Reference£º
Patent; Zhejiang Hongyuan Pharmaceutical Co., Ltd.; Wang Haibo; Mei Guangyao; Jin Hui; Zhang Wei; Liu Xuesheng; Lin Wenjing; Wang Kaiming; (20 pag.)CN108675976; (2018); A;,
Tetrahydrofuran – Wikipedia
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