With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.
Compound VIII-5 (400 mg, 0.90 mmol) and 3-aminotetrahydrofuran (IX-8) (48 mg, 1.35 mmol) were dissolved in sec-butanol (3 mL), and the mixture was heated to 125 C for 12 h, until TLC (two Methyl chloride: methanol = 25:1) The starting material VIII-5 was reacted completely, the reaction solution was cooled to room temperature, and the solvent was evaporated to dryness under reduced pressure.200:1 to 50:1), obtained as a white solid, 220 mg, yield: 54.2%
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Reference£º
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Lingzhi; Zhu Qihua; Bai Ying; Wu Yaoyao; (41 pag.)CN109608444; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem