184950-35-4, (Tetrahydrofuran-3-yl)methanamine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5 – [(2-naphthylmethyl) thiomethyl] isoxazole-3-carboxylic acid chloride ( In ethyl acetate solution (30 mL) Tetrahydrofuran-3-ylmethylamine hydrochloride (1.00 g, 7.26 mmol) And 1 mol / L sodium hydroxide aqueous solution (16 mL) Were simultaneously added at room temperature. After vigorously stirring at room temperature for 1 hour, 1 mol / L sodium hydroxide aqueous solution was added. The separated organic layer was washed successively with water and saturated brine, After drying over anhydrous magnesium sulfate, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Represented by the following equation N- (tetrahydrofuran-3-ylmethyl) -5 – [(2-naphthylmethyl) thiomethyl] isoxazole-3-carboxamide (Hereinafter referred to as present amide compound (253)) 480 mg was obtained.
The synthetic route of 184950-35-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
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