With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.
General procedure: Anhydrous K2CO3 (5 equiv) was added to the solution of relevantamine (1 equiv) and tetrabutylammonium bromide (TBAB)(0.01 equiv) in the acetonitrile and the mixture was stirred at at0 C for 1.5 h. Then a solution of 3-bromodihydrofuran-2(3H)-one(8) or 3-bromo-5-methyldihydrofuran-2(3H)-one (9) (1 equiv)was added dropwise and stirring was continued for 12-48 h atroom temperature. After the reaction was completed, the precipitatewas filtered off and the filtrate was concentrated under vacuum.Obtained crude products were purified by columnchromatography. Reagents and conditions: 6.03mmol 4 (1.43g), 30.19mmol K2CO3 (4.17g), 0.06mmol TBAB (0.02g), 6.03mmol 8 (1.00g), 15ml MeCN, 48h; purification by column chromatography (S6); Yield 78%; yellow oil; Rf: 0.70 (S6); 1H NMR (CDCl3) delta [ppm]: 2.17-2.20ppm (m, 2H(CH2CH2N)), 2.23-2.30 (m, 2H(NCHCH2)) 2.31 (s, 3H (Me)), 2.68-2.74ppm (t, 2H (CH2N)), 3.62-3.68ppm (t, 1H(NCH)), 4.13-4.37ppm (m, 2H(CH2CH2O), 6.13 (t, 1H(C=CH)), 7.17-7.40ppm (m, 10H (Ar)), ESI-MS (m/z) 322.1 [M+H]+
5061-21-2 2-Bromo-4-butanolide 95463, aTetrahydrofurans compound, is more and more widely used in various.
Reference£º
Article; Kowalczyk, Paula; Sa?at, Kinga; Hoefner, Georg C.; Guzior, Natalia; Filipek, Barbara; Wanner, Klaus T.; Kulig, Katarzyna; Bioorganic and Medicinal Chemistry; vol. 21; 17; (2013); p. 5154 – 5167;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem