149809-43-8, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add to 50ml single-mouth reaction bottle1-((2R,3S)-2-(Benzyloxy)-pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)- 1H-1,2,4-triazole-5(4H)-one (1 g, 1.947 mmol, 1 eq.),((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl P-toluenesulfonate (1.03g,2.181mmol, 1.12eq.),DMSO (6 ml) was dissolved by stirring, and 50 wt% NaOH (202.5 mg, 2.531 mmol, 1.3 eq.) was added and stirred at 45 C.TLC showed complete reaction after 2 h.The reaction was dropped into water, stirred, suction filtered, and the filter cake was washed with water (50ml). Isopropanol crystallized to give 1.52g of a white solid, yield 98.7%
As the paragraph descriping shows that 149809-43-8 is playing an increasingly important role.
Reference£º
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Shanghai Pharmaceutical Industry Institute; Huang Huoming; Lv Huimin; Xiao Zhichao; Cai Wei; Ren Zhongjie; Zhou Ting; Liu Zhenren; Zhou Weicheng; Zhang Haibo; (35 pag.)CN108341754; (2018); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem