With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.
In the same apparatus as in Example 1, The residue (Ir-Pt -Re catalyst (1)) obtained in Example 1, and 0.342 g (3.0 mmol) of epsilon-caprolactone were added, It was made up with 1,2-dimethoxyethane to make epsilon-caprolactone 5%. Pressurized to 8.0 MPa with hydrogen gas, the mixture was reacted at 80 C. for 2 hours with stirring. After completion of the reaction, the resulting reaction solution was cooled to room temperature, And then filtered through a syringe equipped with a membrane filter (0.45 mum). When the obtained filtrate was analyzed by gas chromatography, The conversion of epsilon-caprolactone is 100% The yield of 1,6-hexanediol was 92.3%. The selectivity was 92.3% The yield of 1-hexanol was 8.0% The selectivity was 8.0%. In Example 1A, The catalyst was added to the Ir-Pt-Re catalyst (2) prepared in Example 2, A 1,2-dimethoxyethane solution of 5% epsilon-caprolactone was added to 50% gamma-valerolactone 1, To a 2-dimethoxyethane solution (7.5 mmol of gamma-valerolactone) Except for changing the reaction time to 4 hours, The reaction was carried out in the same manner as in Example 1A. When the obtained filtrate was analyzed by gas chromatography, The conversion of gamma-valerolactone was 50.0% . The yield of 1,4-pentanediol was 40.0%. The selectivity was 80.0%. The yield of 2-pentanol was 10.1% . The same selectivity was 20.2%.
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Reference£º
Patent; UBE INDUSTRIES LIMITED; YOSHII, KIYOTAKA; YAMADA, ATSUSHI; (22 pag.)JP2015/86199; (2015); A;,
Tetrahydrofuran – Wikipedia
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