1679-47-6, 3-Methyldihydrofuran-2(3H)-one is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: ethyl 4-bromo-2-methylbutanoateTo a HBr saturated solution of EtOH (100 mL) at 0 C was added a-methyl~y- butyrolactone (3.0 mL, 31.7 mmol). The mixture was allowed to stir at rt for 3 days and then poured onto ice (500 g). After warming to rt, the mixture was extracted with Et20 (2×200 mL). The combined organic layer was further washed with H20 (300 mL) sat. NaHC03 (3×300 mL) and brine (300 mL), dried over MgSC>4, and concentrated to give the title compound, which was used without further purification: 1H NMR (500 MHz, CDC13) delta 4.15 (q, J= 7.1 Hz, 2H), 3.43 (dt, J= 1.1, 6.9 Hz, 2H), 2.68 (m, 1H), 2.26 (m, 2H)5 1.93 (m, 2H), 1.26 (t, J= 7.0 Hz, 3H), 1.19 (d, J= 7.1 Hz, 3H).
The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ALI, Amjad; NARGUND, Ravi; LO, Michael Man-Chu; YAN, Lin; HUO, Pei; FRANKLIN, Christopher; WO2011/53519; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem