112372-15-3, Furo[2,3-c]pyridine-2-carboxylic acid is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 4. A solution of furo[2,3-c]pyndine-2-carboxylic acid (120 mg, 0.74 mmol, 1.48 equiv), 4-(6-methyl-pyridine-3-suIfonyl)-benzyIamine ( 130 mg, 0.50 mmol, 1.00 equiv), EDCI (125 mg, 0.65 mmol, 1 .32 equiv), HOBt (90 mg, 0.67 mmol, 1.34 equiv), and diisopropylethylamine (0.5 mL) in DMF (5 mL) was stirred overnight at rt. After the reaction completed, the resulting solution was diluted with 100 mL of DCM. The mixture was washed with 2×30 mL of water and 2×30 mL of brine. The organic layer was dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was then purified on a silica gel column eluted with DCM/MeOH (93 :7) to give 0.045 g (22%) of the title compound as a white solid. LC/MS (Method C, ESI), RT= 1 .70 min, m/z = 407.8 [M+H]+. 1G NMR (300 MHz, DMSO-d6) 6 9.60 (t, J = 6 0 Hz, 1 H), 9.05 (s, 1 H), 8.97 (d, J = 2.1 Hz, l H), 8.97 (d, J = 5.1 Hz, 1 H), 8.19 (dd, J = 8.1 Hz, J = 2.4 Hz, 1 H), 7.97 (d, J = 8.4 Hz, 2H), 7.81 (d, J = 4.8 Hz, 1 H), 7.64 (s, 1 H), 7.57 (d, J = 8.4 Hz, 2H), 7.47 (d, J = 8.4 Hz, 1 H), 4.55 (d, J = 6.0 Hz, 2H), 2.54 (s, 3H).
The synthetic route of 112372-15-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling; WO2013/127268; (2013); A1;,
Tetrahydrofuran – Wikipedia
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